Codeine

Codeine

Codeine is an opioid pain-relief medicine used for the short-term relief of mild to moderate pain. · It is not usually recommended for the treatment of chronic . Codeine Phosphate 30mg 100 Tablets, available to buy online with a prescription at Pharmacy2U, for the treatment of pain. Discreet packaging for all .

Is a strong analgesic and provides relief from moderate pain. Buy Codeine online.
 

Codeine

Codeine is used to relieve mild to moderate pain. It is also used, usually in combination with other medications, to reduce coughing. Codeine will help relieve symptoms but will not treat the cause of symptoms or speed recovery. it belongs to a class of medications called opiate (narcotic) analgesics and to a class of medications called antitussives. When it is used to treat pain, it works by changing the way the brain and nervous system respond to pain. When codeine is used to reduce coughing, it works by decreasing the activity in the part of the brain that causes coughing.

Codeine is also available in combination with acetaminophen (Capital and Codeine, Tylenol with Codeine), aspirin, carisoprodol, and promethazine and as an ingredient in many cough and cold medications. This monograph only includes information about the use of it . If you are taking a codeine combination product, be sure to read information about all the ingredients in the product you are taking and ask your doctor or pharmacist for more information.

 
Cody
Codeine is an opiate and prodrug of morphine used to treat pain, coughing, and diarrhea.It is found naturally in the sap of the opium poppy, Papaver somniferum. It is typically used to treat mild to moderate degrees of pain.
Captain Cody
Codeine is another type of prescription medication used for pain relief and as a cough suppressant or cold medicine.
Lean
Codeine is often misused by mixing it with alcohol or another sedative. This has been largely popularized in pop culture through songs that glamorize using it as a means of getting high.
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Purple drank
Codeine Phosphate 30mg 100 Tablets, available to buy online with a prescription at Pharmacy2U, for the treatment of pain. Discreet packaging
Sizzurp
The most powerful pain relievers are opioids. They are very effective, but they can sometimes have serious side effects.
Pancakes and syrup
Cough medicines with codeine can be bought at drugstores without a prescription in a few states. Codeine is also in pain relievers along with acetaminophen.
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Codeine

Codeine: learn about side effects, dosage, special precautions, and more. Codeine is an opioid pain-relief medicine used for the short-term relief of mild to moderate pain. · It is not usually recommended for the treatment of chronic. part of a group of drugs known as opioids which interact with receptors in the brain and can elicit feelings of pain relief. it is a medication used in the management and treatment of chronic pain. It is in the opioid class of medications. it is a weak narcotic pain reliever and cough suppressant that is similar to morphine and hydrocodone. it is used to relieve mild to moderate pain. It belongs to the group of medicines called narcotic analgesics (pain medicines).Medscape – Antitussive, pain-specific dosing for, frequency-based adverse effects, comprehensive interactions, contraindications, Codeine is an opioid pain reliever used to treat mild to moderately severe pain. It is also used .

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codeine phosphate


Codeine. Revised 03/2021. West-Ward Pharmaceuticals Corp. 
Further information
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use codeine only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. May not be suitable for some people including children of any age who have undergone a tonsillectomy or adenoidectomy, people with pre-existing respiratory depression or respiratory disease, with seizure disorders or a head injury, people with gastrointestinal obstruction, or recent use of monoamine oxidase inhibitors.
Should not be used during pregnancy or breastfeeding unless specifically recommended and monitored by a doctor. Can cause life-threatening withdrawal symptoms in a newborn.

Nearly $150,000 worth of codeine was seized near Tucson on Monday.

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Codeine is addictive (habit-forming) and potentially abusable. should only be used short-term at the lowest effective dose and only when other nonopioid analgesics are not effective. Tolerance can also develop to codeine’s analgesic effect (this means that the same dose does not provide as much pain relief as before). Legitimate supplies of products containing codeine may be sought out by drug seekers.
Abrupt discontinuation of the bottle in a person who has become physically dependent on it may lead to a withdrawal syndrome and symptoms such as restlessness, pupil dilation, watery eyes and a runny nose, sweating, muscle aches, insomnia, irritability and gastrointestinal complaints.

Rarely, serious, life-threatening, breathing problems may occur attributable to the component. The risk is greater with higher dosages of it, in people with pre-existing respiratory disease, in seniors or the frail, or in those taking other medications that cause respiratory depression (such as benzodiazepines). Not for use in children under the age of 18.
Codeine may interact with several drugs, including those that affect hepatic enzymes CYP 3A4 or CYP 2D6, and those that also cause respiratory depression (such as other opioids, benzodiazepines, and alcohol).
Interaction or overdosage may also cause serotonin syndrome. Symptoms include mental status changes such as agitation, hallucinations, coma, or delirium; a fast heart rate; dizziness; flushing; muscle tremor or rigidity; and stomach symptoms (including nausea, vomiting, and diarrhea).
Long-term use of cough medicine also affects the endocrine system, which may cause symptoms such as sexual dysfunction, an absence of periods, or infertility.

codeine 30mg

Codeine is an opiate and prodrug of morphine used to treat pain, coughing, and diarrhea.It is found naturally in the sap of the opium poppy, Papaver somniferum. It is typically used to treat mild to moderate degrees of pain. 

Drowsiness or dizziness which may impair reaction skills and affect a person’s ability to drive or operate machinery. Avoid alcohol.
also slows down the motility of the gastrointestinal tract. This can lead to symptoms such as nausea, vomiting, constipation, and abdominal pain. Laxatives may be required.
may also affect blood pressure, manifesting as dizziness when standing; and stimulate histamine release, which may cause symptoms such as flushing, itchiness, sweating, or red eyes.

Babies born to mothers who are physically dependent on it will also be physically dependent.
Marked differences may exist in the analgesic effect provided by due to genetic variations in the CYP 2D6 liver enzyme responsible for metabolizing into morphine. Consider alternative analgesics if codeine is not having the desired pain-relieving effect.

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Note that this list is not all-inclusive and includes only common medications that may interact with it. You should refer to the prescribing information for it for a complete list of interactions.

codeine comprimé

Do not double up on other medications containing it (several cold and flu remedies also contain this ).
Avoid alcohol while taking . Alcohol can contribute to the sedative effects of and also increase the risk of respiratory depression.
may make you feel dizzy when getting up from a lying down or sitting position to standing. Always get up slowly, but talk with your doctor if this dizziness results in a fall.
Codeine may cause constipation which can be relieved with laxatives. Drink 6 to 8 full glasses of water daily to prevent this effect. Talk to your doctor if you experience any troublesome side effects of before using a laxative..
Seek urgent medical advice if you experience any excessive sedation, breathing difficulties, wheezing, rash, itching, or facial swelling. Call emergency services if you suspect somebody has overdosed on (pinpoint pupils may be indicative of overdosage).
Do not use during pregnancy or breastfeeding unless specifically recommended by your doctor.
Keep this medicine in a safe place and out of the reach of children and pets. Accidental ingestion can result in a fatal overdose of it , especially in children. Never give it to children under the age of 18.

Codeine

Codeine, an opioid analgesic, was originally approved in the US in 1950 and is a drug used to decrease pain by increasing the threshold for pain. Codeine may cause serious or life-threatening breathing problems, especially during the first 24 to 72 hours of your treatment . It is a medication used in the management and treatment of chronic pain. It is in the opioid class of medications. This is an oral prescription opioid (narcotic) drug most commonly used to treat mild-to-moderate pain, as a cough suppressant . is an opioid pain-relief medicine used for the short-term relief of mild to moderate pain. · It is not usually recommended for the treatment of chronic . 

IMPORTANT WARNING:

Codeine may be habit forming. Take it exactly as directed. Do not take more of it, take it more often, or take it in a different way than directed by your doctor. While taking codeine, discuss with your healthcare provider your pain treatment goals, length of treatment, and other ways to manage your pain. Tell your doctor if you or anyone in your family drinks or has ever drunk large amounts of alcohol, uses or has ever used street drugs, or has overused prescription medications, or has had an overdose, or if you have or have ever had depression or another mental illness. There is a greater risk that you will overuse . if you have or have ever had any of these conditions. Talk to your healthcare provider immediately and ask for guidance if you think that you have an opioid addiction or call the U.S. Substance Abuse and Mental Health Services Administration (SAMHSA) National Helpline at 1-800-662-HELP.

Codeine may cause serious or life-threatening breathing problems, especially during the first 24 to 72 hours of your treatment and any time your dose is increased. Your doctor will monitor you carefully during your treatment. Tell your doctor if you have or have ever had slowed breathing or asthma. Your doctor will probably tell you not to take codeine. Also tell your doctor if you have or have ever had lung disease such as chronic obstructive pulmonary disease (COPD; a group of diseases that affect the lungs and airways), a head injury, brain tumor, or any condition that increases the amount of pressure in your brain. The risk that you will develop breathing problems may be higher if you are an older adult or are weak or malnourished due to disease. If you experience any of the following symptoms, call your doctor immediately or get emergency medical treatment: slowed breathing, long pauses between breaths, or shortness of breath.

When codeine was used in children, serious and life-threatening breathing problems such as slow or difficulty breathing and deaths were reported. Codeine should never be used to treat pain or a cough in children younger than 18 years of age. If your child is currently prescribed a cough and cold medicine containing it , talk to your child’s doctor about other treatments.

Taking certain medications during your treatment with it may increase the risk that you will experience breathing problems or other serious, life-threatening breathing problems, sedation, or coma. Tell your doctor if you are taking or plan to take any of the following medications: certain antibiotics such as erythromycin (Erytab, Erythrocin); certain antifungal medications including ketoconazole; benzodiazepines such as alprazolam (Xanax), diazepam (Diastat, Valium), estazolam, flurazepam, lorazepam (Ativan), and triazolam (Halcion); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril); certain medications for human immunodeficiency virus (HIV) including indinavir (Crixivan), nelfinavir (Viracept), and ritonavir (Norvir, in Kaletra); medications for mental illness or nausea; other medications for pain; muscle relaxants; phenytoin (Dilantin, Phenytek); rifampin (Rifadin, Rimactane, in Rifamate); sedatives; sleeping pills; or tranquilizers. Your doctor may need to change the dosages of your medications and will monitor you carefully. If you take codeine with any of these medications and you develop any of the following symptoms, call your doctor immediately or seek emergency medical care: unusual dizziness, lightheadedness, extreme sleepiness, slowed or difficult breathing, or unresponsiveness. Be sure that your caregiver or family members know which symptoms may be serious so they can call the doctor or emergency medical care if you are unable to seek treatment on your own.

Drinking alcohol or using street drugs during your treatment is also increases the risk that you will experience these serious, life-threatening side effects. Do not drink alcohol, take prescription or nonprescription medications that contain alcohol, or use street drugs during your treatment.

Tell your doctor if you are pregnant or plan to become pregnant. If you take its regularly during your pregnancy, your baby may experience life-threatening withdrawal symptoms after birth. Tell your baby’s doctor right away if your baby experiences any of the following symptoms: irritability, hyperactivity, abnormal sleep, high-pitched cry, uncontrollable shaking of a part of the body, vomiting, diarrhea, or failure to gain weight.

Do not allow anyone else to take your medication. Codeine may harm or cause death to other people who take your medication, especially children.

Your doctor or pharmacist will give you the manufacturer’s patient information sheet (Medication Guide) when you begin treatment with it and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer’s website to obtain the Medication Guide.

Why is this medication prescribed?

Codeine is used to relieve mild to moderate pain. It is also used, usually in combination with other medications, to reduce coughing. Codeine will help relieve symptoms but will not treat the cause of symptoms or speed recovery. it belongs to a class of medications called opiate (narcotic) analgesics and to a class of medications called antitussives. When codeine is used to treat pain, it works by changing the way the brain and nervous system respond to pain. When codeine is used to reduce coughing, it works by decreasing the activity in the part of the brain that causes coughing.

Codeine is also available in combination with acetaminophen (Capital and Codeine, Tylenol with Codeine), aspirin, carisoprodol, and promethazine and as an ingredient in many cough and cold medications. This monograph only includes information about the use of it . If you are taking a combination product, be sure to read information about all the ingredients in the product you are taking and ask your doctor or pharmacist for more information.

How should this medicine be used?

Codeine (alone or in combination with other medications) comes as a tablet, a capsule, and a solution (liquid) to take by mouth. It is usually taken every 4 to 6 hours as needed. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take codeine exactly as directed.

If you have taken codeine for several weeks or longer, do not stop taking the medication without talking to your doctor. Your doctor may decrease your dose gradually. If you suddenly stop taking it , you may experience withdrawal symptoms such as restlessness, widened pupils (black circles in the center of the eyes), teary eyes, irritability, anxiety, runny nose, difficulty falling asleep or staying asleep, yawning, sweating, fast breathing, fast heartbeat, chills, hair on your arms standing on end, nausea, loss of appetite, vomiting, diarrhea, stomach cramps, muscle aches, or backache.

Shake the solution well before each use to mix the medication evenly. Do not use a household spoon to measure your dose. Use the measuring cup or spoon that came with the medication or use a spoon that is made especially for measuring medication.

Other uses for this medicine

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking codeine,

  • tell your doctor and pharmacist if you are allergic to it , any other medications, or any of the ingredients in the product you plan to take. Ask your doctor or pharmacist for a list of the ingredients.
  • tell your doctor or pharmacist if you are taking or receiving the following monoamine oxidase (MAO) inhibitors or if you have stopped taking them within the past 2 weeks: isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate). Your doctor will probably tell you not to take it. if you are taking one or more of these medications, or have taken them within the past 2 weeks.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: bupropion (Aplenzin, Wellbutrin, Zyban); cyclobenzaprine (Amrix); diuretics (‘water pills’); lithium (Lithobid); medications for cough, cold, or allergies; medications for anxiety or seizures; medications for migraine headaches such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex, in Treximet), and zolmitriptan (Zomig); mirtazapine (Remeron); 5HT3serotonin blockers such as alosetron (Lotronex), dolasetron (Anzemet), granisetron (Kytril), ondansetron (Zofran, Zuplenz), or palonosetron (Aloxi); selective serotonin-reuptake inhibitors such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Prozac, Pexeva), and sertraline (Zoloft); serotonin and norepinephrine reuptake inhibitors such as duloxetine (Cymbalta), desvenlafaxine (Khedezla, Pristiq), milnacipran (Savella), and venlafaxine (Effexor); tramadol (Conzip); trazodone (Oleptro); and tricyclic antidepressants (‘mood elevators’) such as amitriptyline, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Silenor), imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil). Many other medications may also interact with codeine, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor what herbal products you are taking, especially St. John’s wort and tryptophan.
  • tell your doctor if you have any of the conditions mentioned in the IMPORTANT WARNING section, a blockage or narrowing of your stomach or intestines, or paralytic ileus (condition in which digested food does not move through the intestines). Your doctor may tell you not to take it .
  • tell your doctor if you drink or have had recent abdominal or urinary tract surgery. Also tell your doctor if you have or have ever had seizures; mental illness; prostatic hypertrophy (enlargement of a male reproductive gland); urinary problems; low blood pressure; Addison’s disease (condition in which the body does not make enough of certain natural substances); or thyroid, pancreatic, intestinal, gallbladder, liver, or kidney disease.
  • you should know that this medication may decrease fertility in men and women. Talk to your doctor about the risks of taking codeine.
  • tell your doctor if you are breastfeeding. You should not breastfeed while taking codeine. Codeine can cause shallow breathing, difficulty or noisy breathing, confusion, more than usual sleepiness, trouble breastfeeding, or limpness in breastfed infants.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking it .
  • you should know that this medication may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.
  • you should know that codeine may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking codeine. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.
  • you should know that it may cause constipation. Talk to your doctor about changing your diet and using other medications to treat or prevent constipation.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?

Codeine is usually taken as needed. If your doctor has told you to take it regularly, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Codeine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • headache
  • stomach pain
  • difficulty urinating

Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNINGS section, stop taking it and call your doctor immediately or get emergency medical attention:

  • agitation, hallucinations (seeing things or hearing voices that do not exist), fever, sweating, confusion, fast heartbeat, shivering, severe muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea
  • nausea, vomiting, loss of appetite, weakness, or dizziness
  • inability to get or keep an erection
  • irregular menstruation
  • decreased sexual desire
  • noisy or shallow breathing
  • difficulty breathing or swallowing
  • changes in heartbeat
  • rash
  • itching
  • hives
  • changes in vision
  • seizures

Codeine may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at 911.

While taking it , you should talk to your doctor about having a rescue medication called naloxone readily available (e.g., home, office). Naloxone is used to reverse the life-threatening effects of an overdose. It works by blocking the effects of opiates to relieve dangerous symptoms caused by high levels of opiates in the blood. Your doctor may also prescribe you naloxone if you are living in a household where there are small children or someone who has abused street or prescription drugs. You should make sure that you and your family members, caregivers, or the people who spend time with you know how to recognize an overdose, how to use naloxone, and what to do until emergency medical help arrives. Your doctor or pharmacist will show you and your family members how to use the medication. Ask your pharmacist for the instructions or visit the manufacturer’s website to get the instructions. If symptoms of an overdose occur, a friend or family member should give the first dose of naloxone, call 911 immediately, and stay with you and watch you closely until emergency medical help arrives. Your symptoms may return within a few minutes after you receive naloxone. If your symptoms return, the person should give you another dose of naloxone. Additional doses may be given every 2 to 3 minutes, if symptoms return before medical help arrives.

Symptoms of overdose may include the following:

  • difficulty breathing
  • slow or shallow breathing
  • excessive drowsiness or sleepiness
  • unable to respond or wake up
  • loss of muscle tone
  • cold and clammy skin
  • fainting
  • dizziness
  • slow heartbeat

What other information should I know?

Keep all appointments with your doctor and laboratory. Your doctor will order certain lab tests to check your body’s response .

Before having any laboratory test (especially those that involve methylene blue), tell your doctor and the laboratory personnel that you are taking codeine.

Selling or giving away this medication may cause death or harm to others and is illegal. Your prescription might not be refillable. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names

  • Tuzistra XR® (as a combination product containing Chlorpheniramine, Codeine)

Brand names of combination products

  • Airacof® (containing Codeine, Diphenhydramine, Phenylephrine)
  • Ala-Hist AC® (containing Codeine, Phenylephrine)
  • Allfen CD® (containing Codeine, Guaifenesin)
  • Ambenyl® (containing Bromodiphenhydramine, Codeine)
  • Ambophen® (containing Bromodiphenhydramine, Codeine)
  • Antituss AC® (containing Codeine, Guaifenesin)
  • Bitex® (containing Codeine, Guaifenesin)
  • Bromanyl® (containing Bromodiphenhydramine, Codeine)
  • Bromotuss® with Codeine (containing Bromodiphenhydramine, Codeine)
  • Brontex® (containing Codeine, Guaifenesin)
  • Bron-Tuss® (containing Codeine, Guaifenesin)
  • Brovex CB® (containing Brompheniramine, Codeine)
  • Brovex PBC® (containing Brompheniramine, Codeine, Phenylephrine)
  • Calcidrine® (containing Anhydrous Calcium Iodide, Codeine)
  • Cheracol® with Codeine (containing Codeine, Guaifenesin)
  • Cheratussin® (containing Codeine, Guaifenesin)
  • Codafen® (containing Codeine, Guaifenesin)
  • Codimal PH® (containing Codeine, Phenylephrine, Pyrilamine)
  • Cotab A® (containing Chlorpheniramine, Codeine)
  • Demi-Cof® (containing Chlorpheniramine, Codeine, Phenylephrine, Potassium Iodide)
  • Dex-Tuss® (containing Codeine, Guaifenesin)
  • Diabetic Tussin C® (containing Codeine, Guaifenesin)
  • Dicomal-PH® (containing Codeine, Phenylephrine, Pyrilamine)
  • Duraganidin NR® (containing Codeine, Guaifenesin)
  • EndaCof AC® (containing Brompheniramine, Codeine)
  • Endal CD® (containing Codeine, Diphenhydramine, Phenylephrine)
  • ExeClear-C® (containing Codeine, Guaifenesin)
  • Gani-Tuss NR® (containing Codeine, Guaifenesin)
  • Giltuss Ped-C® (containing Codeine, Guaifenesin, Phenylephrine)
  • Glydeine® (containing Codeine, Guaifenesin)
  • Guaifen AC® (containing Codeine, Guaifenesin)
  • Guiatuss AC® (containing Codeine, Guaifenesin)
  • Guiatussin® with Codeine, Guaifenesin)
  • Halotussin AC® (containing Codeine, Guaifenesin)
  • Iophen® (containing Codeine, Guaifenesin)
  • Mar-cof CG® (containing Codeine, Guaifenesin)
  • Maxiphen CD® (containing Codeine, Guaifenesin, Phenylephrine)
  • M-Clear WC® (containing Codeine, Guaifenesin)
  • M-End PE® (containing Brompheniramine, Codeine, Phenylephrine)
  • Mytussin AC® (containing Codeine, Guaifenesin)
  • Nalex® AC (containing Brompheniramine, Codeine)
  • Notuss AC® (containing Chlorpheniramine, Codeine)
  • Notuss PE® (containing Codeine, Phenylephrine)
  • Pediacof® (containing Chlorpheniramine, Codeine, Phenylephrine, Potassium Iodide)
  • Pedituss® (containing Chlorpheniramine, Codeine, Phenylephrine, Potassium Iodide)
  • Pentazine VC® (containing Codeine, Phenylephrine, Promethazine)
  • Pentazine® with Codeine (containing Codeine, Promethazine)
  • Phenergan® VC with Codeine (containing Codeine, Phenylephrine, Promethazine)
  • Phenergan® with Codeine (containing Codeine, Promethazine)
  • Poly-Tussin AC® (containing Brompheniramine, Codeine, Phenylephrine)
  • Prometh® with Codeine (containing Codeine, Guaifenesin, Promethazine)
  • Robafen AC® (containing Codeine, Guaifenesin)
  • Robichem AC® (containing Codeine, Guaifenesin)
  • Robitussin® AC (containing Codeine, Guaifenesin)
  • Rolatuss® (containing Ammonium Chloride, Chlorpheniramine, Codeine, Phenylephrine)
  • Romilar AC® (containing Codeine, Guaifenesin)
  • Tusnel C® (containing Brompheniramine, Codeine, Guaifenesin)
  • Tussi Organidin® (containing Codeine, Guaifenesin)
  • Tussiden C® ( Guaifenesin)
  • Tussirex® (containing Caffeine, Codeine, Pheniramine, Phenylephrine, Salicylic Acid)
  • Tusso-C® (containing Codeine, Guaifenesin)
  • Vanacof® (containing Codeine, Dexchlorpheniramine, Phenylephrine)
  • Z Tuss AC® (containing Chlorpheniramine, Codeine)
  • Zodryl AC® (containing Chlorpheniramine, Codeine)
  • Zotex C® (containing Codeine, Phenylephrine, Pyrilamine)

This branded product is no longer on the market. Generic alternatives may be available.

1. How it works
Codeine is an opioid analgesic (pain-reliever) that is related to morphine.
Codeine works by weakly binding to a specific opioid receptor, known as the mu-opioid receptor, but with much less affinity than morphine, which means its analgesic (pain-relieving effects) are much less.
Codeine belongs to the group of drugs known as opioids or opioid analgesics. Codeine may also be called a narcotic analgesic.
2. Upsides
May be used to treat mild-to-moderate pain that is unrelieved by nonopioid analgesics.
Generic codeine is available.
3. Downsides
If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

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Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. View complete list of side effects

4. Bottom Line
Codeine is an effective pain-reliever; however, it is addictive, may cause constipation, and its pain-relieving effects vary markedly between individuals. should only be used for pain relief when other simpler analgesics, such as acetaminophen or ibuprofen, are not appropriate.
5. Tips
May be taken with or without food. Do not take more than you have been prescribed. Codeine should be used short-term only. Long-term use may lead to addiction and dependence. may need to be discontinued slowly depending on the duration of use. Talk to your doctor about a tapering schedule. Never share your it with anyone. Do not keep your leftover medicine. Ask your pharmacy when the next take-back program is.
May cause sedation and affect your ability to drive or operate machinery. Do not drive or perform other hazardous tasks if it affects you in this way.
Use short-term (three days or less) only. Not recommended for long-term use.
Tell your doctor if you think you have become addicted to it or the usual dosage does not appear to be working.

6. Response and effectiveness
The analgesic effect of reaches a peak in about two hours and the effects last for between four to six hours.
About 70-80% of a dose of it is metabolized by the liver into a number of metabolites, some active and some inactive. One of these active metabolites is morphine. About 5-10% of it is metabolized into morphine by the hepatic enzyme, CYP2D6. Experts believe some of the analgesic properties of it are due to it being converted into morphine. Note that up to 10% of Caucasians, 6% of Mexican-Americans, and 5% of African-Americans are poor metabolizers at CYP2D6 and are unlikely to metabolize codeine into morphine. 30% of Ethiopians, 20% of Saudis, 10% of Portuguese and Greeks, and 4% of North Americans are ultra-rapid metabolizers at CYP 2D6 and may experience excessive side effects, such as extreme sleepiness, confusion, and shallow breathing, even with normal dosages of it
7. Interactions
Medicines that interact with may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with it . An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed.

Common medications that may interact :

antibiotics, such as erythromycin
antidepressants, such as tricyclic antidepressants (eg, amitriptyline), monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine), or SSRIs (eg, fluoxetine, sertraline)
antifungal agents, such as itraconazole and ketoconazole
anticonvulsants, such as carbamazepine, lamotrigine, phenytoin, phenobarbital, or primidone
antimigraine agents such as sumatriptan
antipsychotics (such as butyrophenones, phenothiazines, or thioxanthenes) and atypical antipsychotics (eg, olanzapine, quetiapine, ziprasidone)
any medication that may cause drowsiness, such as amphetamines, azelastine, benzodiazepines (eg, diazepam, lorazepam), first-generation antihistamines (such as doxylamine or promethazine), metoclopramide, or opioids (such as hydrocodone, morphine)
buprenorphine
HIV medications such as darunavir or ritonavir
muscle relaxants, such as cyclobenzaprine
naltrexone
other medications that are CYP2D6 or CYP3A4 inhibitors or inducers
pentazocine
rifampin.
Avoid drinking alcohol or taking illegal or recreational drugs while taking codeine.

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